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ARHGAP24 Polyklonaler Antikörper

ARHGAP24 Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Hund, Maus, Ratte

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 18834-1-PBS

Synonyme

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  • Immunohistochemistry (IHC) staining of human kidney tissue using ARHGAP24 Polyclonal antibody (18834-1-AP)

    IHC staining of human kidney using 18834-1-AP (same clone as 18834-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 18834-1-AP (ARHGAP24 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 18834-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human kidney tissue using ARHGAP24 Polyclonal antibody (18834-1-AP)

    IHC staining of human kidney using 18834-1-AP (same clone as 18834-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 18834-1-AP (ARHGAP24 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 18834-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

18834-1-PBS bindet in IHC, Indirect ELISA ARHGAP24 und zeigt Reaktivität mit human, Hund, Maus, Ratten

Getestete Reaktivität human, Hund, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name Rho GTPase activating protein 24
Berechnetes Molekulargewicht 84 kDa
Beobachtetes Molekulargewicht 73 kDa
GenBank-ZugangsnummerBC098580
Gene symbol ARHGAP24
Gene ID (NCBI) 83478
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ARHGAP24, also named as FILGAP, is involved in cell polarity, cell morphology and cytoskeletal organization. ARHGAP24 acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. ARHGAP24 controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. ARHGAP24 can suppress the activity of RAC1 and CDC42 in vitro. Its overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. The antibody may recognize all the isoforms of ARHGAP24 except isoform 5.