GRAF Rekombinanter Antikörper

GRAF Rekombinant Antikörper für WB, Cytometric bead array, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Cytometric bead array, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

240086A11

Kat-Nr. : 83206-1-PBS

Synonyme

ARHGAP26, 240086A11, GRAF1, KIAA0621, Oligophrenin 1 like protein

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  WB analysis using 83206-1-RR (same clone as 83206-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83206-1-RR (GRAF antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83206-1-PBS in a different storage buffer formulation.

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  Cytometric bead array standard curve of MP00157-1

  Cytometric bead array standard curve of MP00157-1, ARHGAP26 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 83206-2-PBS. Detection antibody: 83206-1-PBS. Standard: Ag12008. Range: 0.625-20 ng/mL.

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Geprüfte Anwendungen

Produktinformation

83206-1-PBS bindet in WB, Cytometric bead array, Indirect ELISA GRAF und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: GRAF fusion protein Ag12008
• Vollständiger Name: Rho GTPase activating protein 26
• Berechnetes Molekulargewicht: 759 aa, 86 kDa
• Beobachtetes Molekulargewicht: 92-100 kDa
• GenBank-Zugangsnummer: BC068555
• Gene symbol: ARHGAP26
• Gene ID (NCBI): 23092
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GTPase Regulator Associated with Focal Adhesion Kinase (GRAF), also known as Rho GTPase activating protein 26 (ARHGAP26) , is a GTPase-activating protein and inhibits the activity of Rho GTPases by promoting the hydrolytic ability of Rho GTPases. GRAF enhances the hydrolysis of GTPases and converts GTPases from an active form to an inactive form, thereby inhibiting signaling transduction. Deletion and mutation of ARHGAP26 can lead to promyelocytic leukemia, suggesting tumor suppressive activity of ARHGAP26. ARHGAP26 was downregulated in glioblastoma and associated with cell proliferation and migration (PMID: 10908648, PMID: 17611651, PMID: 31004081).