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ASAH2-Specific Polyklonaler Antikörper

ASAH2-Specific Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 19513-1-AP

Synonyme

Acylsphingosine deacylase 2, ASAH2, hCD, HNAC1, LCDase, N CDase, NCDase, Neutral ceramidase, Non lysosomal ceramidase

Geprüfte Anwendungen

Produktinformation

19513-1-AP bindet in ELISA ASAH2-Specific und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Berechnetes Molekulargewicht 86 kDa
GenBank-ZugangsnummerNM_019893
Gene symbol ASAH2
Gene ID (NCBI) 56624
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS with 0.02% sodium azide and 50% glycerol
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ASAH2, also named as HNAC1, belongs to the neutral ceramidase family. ASAH2 catalyze the reaction: N-acylsphingosine + H2O = a carboxylate + sphingosine. ASAH2 hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. ASAH2 acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. And ASAH2 acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. ASAH2 is probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.