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ASXL1 Rekombinanter Antikörper

ASXL1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241563A5

Kat-Nr. : 84630-1-PBS

Synonyme

241563A5, Additional sex combs-like protein 1, KIAA0978, Polycomb group protein ASXL1

Filter:
  • Western Blot (WB) analysis of various lysates using ASXL1 Recombinant antibody (84630-1-RR)

    WB analysis using 84630-1-RR (same clone as 84630-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84630-1-RR (ASXL1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84630-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84630-1-RR

    Affinity and Kinetic Characterization of 84630-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84630-1-RR against Human ASXL1 were performed. The affinity constant is 39.3 nM.

Geprüfte Anwendungen

Produktinformation

84630-1-PBS bindet in WB, Indirect ELISA ASXL1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen ASXL1 fusion protein Ag10290
Vollständiger Name additional sex combs like 1 (Drosophila)
Berechnetes Molekulargewicht84aa,10 kDa; 1541aa,165 kDa
Beobachtetes Molekulargewicht200-220 kDa
GenBank-ZugangsnummerBC064984
Gene symbol ASXL1
Gene ID (NCBI) 171023
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Additional sex combs-like 1 (ASXL1) is a member of the ASXL family, which is involved in epigenetic regulation. It is one of the mammalian Asx homologs. Mutations in the ASXL1 gene are frequently found in myeloid neoplasms, breast cancers, and prostate cancers (PMID: 30013160; PMID: 22436456; PMID: 26470845). In patients with myeloid malignancies, ASXL1 mutations are mostly heterozygous frameshift or nonsense mutations that result in C-terminal truncation (PMID: 30982744; PMID: 26095772; PMID: 32683582; PMID: 29643185).