ATF7IP Polyklonaler Antikörper

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• KD/KO Validated

ATF7IP Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 14699-1-PBS

Synonyme

ATF-interacting protein, ATFa-associated modulator, ATF7-interacting protein, ATF7, ATF

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  IHC staining of human breast cancer using 14699-1-AP (same clone as 14699-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 14699-1-AP (same clone as 14699-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human ovary tumor using 14699-1-AP (same clone as 14699-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach cancer using 14699-1-AP (same clone as 14699-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach cancer using 14699-1-AP (same clone as 14699-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

14699-1-PBS bindet in IHC, Indirect ELISA ATF7IP und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: ATF7IP fusion protein Ag6341
• Vollständiger Name: activating transcription factor 7 interacting protein
• Berechnetes Molekulargewicht: 137 kDa
• GenBank-Zugangsnummer: BC063855
• Gene symbol: ATF7IP
• Gene ID (NCBI): 55729
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ATF7IP (Activating Transcription Factor 7 Interacting Protein), also known as MCAF1 (MBD1-containing chromatin-associated factor 1), is a multifunctional scaffold protein that plays a pivotal role in epigenetic regulation and transcriptional control. Functionally, ATF7IP acts as an adaptor that recruits the histone methyltransferase SETDB1 to specific genomic loci, facilitating the deposition of the heterochromatin mark H3K9me3 and silencing target genes, including retrotransposons such as LINE1. This activity is essential for maintaining genomic stability by suppressing transposable element mobilization and preventing DNA damage.