ATXN1 Polyklonaler Antikörper

ATXN1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 27265-1-PBS

Synonyme

ataxin 1, ataxin1, Ataxin-1, ATX1, ATXN 1

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  WB analysis using 27265-1-AP (same clone as 27265-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27265-1-AP (ATXN1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27265-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

27265-1-PBS bindet in WB, Indirect ELISA ATXN1 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: ATXN1 fusion protein Ag26099
• Vollständiger Name: ataxin 1
• Berechnetes Molekulargewicht: 87 kDa
• Beobachtetes Molekulargewicht: 100 kDa
• GenBank-Zugangsnummer: NM_000332
• Gene symbol: ATXN1
• Gene ID (NCBI): 6310
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Ataxin-1 (ATXN1) is a protein involved in transcriptional regulation and RNA binding. It is a transcriptional repressor that interacts with multiple transcription factors and is associated with large protein complexes. ATXN1 is also involved in the regulation of alternative splicing, as demonstrated by its ability to regulate the splicing of several minigenes. The protein is crucial for normal cerebellar function and is implicated in the pathogenesis of spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder caused by the expansion of a polyglutamine tract in ATXN1 (PMID: 21475249; 20628574).