AXIN2 Monoklonaler Antikörper

AXIN2 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1A11A4

Kat-Nr. : 67458-1-PBS

Synonyme

Axin-2, Axil, axin 2, Axin like protein, Axin-like protein

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  WB analysis using 67458-1-Ig (same clone as 67458-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67458-1-Ig (AXIN2 antibody) at dilution of 1:4800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67458-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

67458-1-PBS bindet in WB, Indirect ELISA AXIN2 und zeigt Reaktivität mit human, Ratten

• Getestete Reaktivität: human, Ratte
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: AXIN2 fusion protein Ag29291
• Vollständiger Name: axin 2
• Berechnetes Molekulargewicht: 843 aa, 94 kDa
• Beobachtetes Molekulargewicht: 100 kDa
• GenBank-Zugangsnummer: BC006295
• Gene symbol: AXIN2
• Gene ID (NCBI): 8313
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Axis inhibition protein2 (AXIN2), also known as Coductin or Axil, is a multidomain scaffold protein that negatively regulate Wnt signaling. AXIN2 can directly interact with beta-catenin and GSK3B. AXIN2 has a number of phosphorylation sites, and also can undergo poly(ADP-ribosy)lation by tankyrase TNKS and TNKS2. Poly(ADP-ribosy)lated AXIN2 then get unbiquitinated by RNF146 and leads to its degradation and subsequent activation of Wnt signaling. AXIN2 is localized in the cytoplasm and its mutation is involved in colorectal cancer.