Adiponectin receptor 1 Monoklonaler Antikörper

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• KD/KO Validated

Adiponectin receptor 1 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1F12B3

Kat-Nr. : 66619-1-PBS

Synonyme

ACDCR1, Adiponectin receptor 1, Adiponectin receptor protein 1, ADIPOR1, CGI 45, CGI45, PAQR1, TESBP1A

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  WB analysis of HEK-293 using 66619-1-Ig (same clone as 66619-1-PBS)

  WB result of Adiponectin receptor 1 antibody (66619-1-Ig; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-Adiponectin receptor 1 transfected HEK-293 cells. This data was developed using the same antibody clone with 66619-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 66619-1-Ig (same clone as 66619-1-PBS)

  HeLa cells, L02 cells, and HepG2 cells were subjected to SDS PAGE followed by western blot with 66619-1-Ig (Adiponectin receptor 1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66619-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

66619-1-PBS bindet in WB, Indirect ELISA Adiponectin receptor 1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Adiponectin receptor 1 fusion protein Ag18187
• Vollständiger Name: adiponectin receptor 1
• Berechnetes Molekulargewicht: 375 aa, 43 kDa
• Beobachtetes Molekulargewicht: 43 kDa
• GenBank-Zugangsnummer: BC010743
• Gene symbol: Adiponectin receptor 1
• Gene ID (NCBI): 51094
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Adiponectin is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Two receptors for adiponectin have been identified: adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2). They are seven-transmembrane domain receptors and mediate increased AMPK, MAPK and PPARA ligand activity in response to adiponectin. AdipoR1 is found in many tissues, being particularly abundant in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver (PMID: 24417942). AdipoR1 has a high affinity for globular adiponectin and a very low affinity for full-length adiponectin. AdipoR2 has an intermediate affinity for both forms. The human ADIPOR1 gene maps to chromosome 1q32.1, and encodes a 375-amino acid protein with a molecular weight of 43 kDa. This antibody was raised against 1-72aa of human AdipoR1.