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Alpha-1-antitrypsin Polyklonaler Antikörper

Alpha-1-antitrypsin Polyklonal Antikörper für WB, IHC, IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, IP, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 25876-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using Alpha-1-antitrypsin Polyclonal antibody (25876-1-AP)

    WB analysis using 25876-1-AP (same clone as 25876-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 25876-1-AP (Alpha-1-antitrypsin antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25876-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of human plasma using Alpha-1-antitrypsin Polyclonal antibody (25876-1-AP)

    IP experiment of human plasma using 25876-1-AP (same clone as 25876-1-PBS)

    IP result of anti-Alpha-1-antitrypsin (IP:25876-1-AP, 4ug; Detection:25876-1-AP 1:3000) with human plasma lysate 1600 ug. This data was developed using the same antibody clone with 25876-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse placenta tissue using Alpha-1-antitrypsin Polyclonal antibody (25876-1-AP)

    IHC staining of mouse placenta using 25876-1-AP (same clone as 25876-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse placenta tissue slide using 25876-1-AP (Alpha-1-antitrypsin antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25876-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

25876-1-PBS bindet in WB, IHC, IP, Indirect ELISA Alpha-1-antitrypsin und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Alpha-1-antitrypsin fusion protein Ag22631
Vollständiger Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Beobachtetes Molekulargewicht 47-50 kDa
GenBank-ZugangsnummerBC011991
Gene symbol Alpha 1-Antitrypsin
Gene ID (NCBI) 5265
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.