Angiotensinogen/AGT Rekombinanter Antikörper

Angiotensinogen/AGT Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251419A5

Kat-Nr. : 86729-1-PBS

Synonyme

AGT, Angiotensinogen, Serpin A8, SERPINA8, Alpha 1 antiproteinase

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  WB analysis of human plasma using 86729-1-RR (same clone as 86729-1-PBS)

  human plasma were subjected to SDS PAGE followed by western blot with 86729-1-RR (Angiotensinogen/AGT antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86729-1-PBS in a different storage buffer formulation.

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  WB analysis of HepG2 using 86729-1-RR (same clone as 86729-1-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 86729-1-RR (Angiotensinogen/AGT antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86729-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

86729-1-PBS bindet in WB, Indirect ELISA Angiotensinogen/AGT und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Angiotensinogen/AGT fusion protein Eg3099
• Vollständiger Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
• Berechnetes Molekulargewicht: 52 kDa
• Beobachtetes Molekulargewicht: 53 kDa
• GenBank-Zugangsnummer: NM_000029.4
• Gene symbol: AGT
• Gene ID (NCBI): 183
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene also have been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.