B7-H3/CD276 Monoklonaler Antikörper

B7-H3/CD276 Monoklonal Antikörper für FC

Wirt / Isotyp

Ratte / IgG1, kappa

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

MJ18

Kat-Nr. : 65221-1-PBS

Synonyme

Cd276, CD276 antigen, B7RP 2, B7-H3, B7h3

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  FC experiment of mouse peritoneal macrophages using 65221-1-Ig (same clone as 65221-1-PBS)

  1X10^6 mouse peritoneal macrophages were surface stained with 1 ug Anti-Mouse CD276 (65221-1-Ig, Clone:MJ18) and FITC anti-rat IgG1 Antibody at dilution 1:100 (red), or unstained (blue). Cells were not fixed. This data was developed using the same antibody clone with 65221-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

65221-1-PBS bindet in FC B7-H3/CD276 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Ratte / IgG1, kappa
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Mouse IgG2a Fc-CD276 (aa 1-242) fusion protein
• Vollständiger Name: CD276 antigen
• GenBank-Zugangsnummer: BC019436
• Gene symbol: Cd276
• Gene ID (NCBI): 102657
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD276 (also known as B7-H3) is a type I transmembrane protein expressed on many tissues and cell types. CD276 is a 100-kDa glycoprotein that belongs to the B7 immunoregulatory family and participates in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 25567370; 20696859). Overexpressed on a wide range of human solid cancers, CD276 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy (PMID: 27208063).