B7-H3/CD276 Rekombinanter Antikörper

B7-H3/CD276 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

230305A10

Kat-Nr. : CL488-98017

Synonyme

CD276, B7-H3, B7H3, B7 homolog 3, B7 H3

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  FC experiment of human monocyte-derived immature dendritic cells using CL488-98017

  1x10^6 human monocyte-derived immature dendritic cells were surface stained with 0.25 ug Coralite® Plus 488 B7-H3/Cd276 Recombinant Antibody (CL488-98017, Clone: 230305A10) (red), or 0.25 ug Coralite® Plus 488 Isotype Control (blue). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: human monocyte-derived immature dendritic cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Produktinformation

CL488-98017 bindet in FC B7-H3/CD276 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: CD276 molecule
• Berechnetes Molekulargewicht: 57 kDa
• GenBank-Zugangsnummer: NM_001024736
• Gene symbol: CD276
• Gene ID (NCBI): 80381
• Konjugation: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 493 nm / 522 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

B7-H3 (CD276) is a type I transmembrane protein expressed on many tissues and cell types. B7-H3 is a 100-kDa glycoprotein that belongs to the B7 immunoregulatory family and participates in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 25567370; 20696859). Overexpressed on a wide range of human solid cancers, B7-H3 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy (PMID: 27208063).