B7-H4 Rekombinanter Antikörper

B7-H4 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Ratte

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250392E12

Kat-Nr. : 98552-2-PBS

Synonyme

B7H4, B7S1, B7x, V-set domain-containing T-cell activation inhibitor 1, Vtcn1

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  FC experiment of Transfected HEK-293T using 98552-2-RR (same clone as 98552-2-PBS)

  1x10^6 HEK-293T cells (left) or B7-H4 transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Rat B7-H4 Rabbit RecAb (98552-2-RR, Clone: 250392E12) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98552-2-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98552-2-RR (same clone as 98552-2-PBS)

  1x10^6 HEK-293T cells (left) or B7-H4 transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Rat B7-H4 Rabbit RecAb (98552-2-RR, Clone:250392E12) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98552-2-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98552-2-PBS bindet in FC B7-H4 und zeigt Reaktivität mit Ratten

• Getestete Reaktivität: Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: B7-H4 fusion protein Eg3230
• Vollständiger Name: V-set domain containing T cell activation inhibitor 1
• Berechnetes Molekulargewicht: 31 kDa
• GenBank-Zugangsnummer: NM_001024244.1
• Gene symbol: Vtcn1
• Gene ID (NCBI): 295322
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

B7-H4, also named VTCN1, B7X, or B7S1, is a single-pass type I membrane protein, which contains two immunoglobulin-like domains and belongs to the immunoglobulin superfamily. B7-H4 negatively regulates T-cell mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. B7-H4 is over-expressed in many cancers, including breast, ovarian, endometrial, renal cell and non-small-cell lung cancers.