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B7-H6 Rekombinanter Antikörper

B7-H6 Rekombinant Antikörper für IF/ICC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, ELISA

Konjugation

Unkonjugiert

CloneNo.

240808B2

Kat-Nr. : 83908-4-PBS

Synonyme

B7H6, NCR3LG1, Natural cytotoxicity triggering receptor 3 ligand 1, B7 homolog 6, B7 H6

Filter:
  • Immunofluorescence (IF) / fluorescent staining of Raji cells using B7-H6 Recombinant antibody (83908-4-RR)

    IF Staining of Raji using 83908-4-RR (same clone as 83908-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Raji cells using B7H6 antibody (83908-4-RR, Clone: 240808B2 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 83908-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83908-4-RR

    Affinity and Kinetic Characterization of 83908-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83908-4-RR against Human B7H6 were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

83908-4-PBS bindet in IF/ICC, ELISA B7-H6 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name hypothetical protein DKFZp686O24166
Berechnetes Molekulargewicht51 kDa
Beobachtetes Molekulargewicht75-80 kDa
GenBank-ZugangsnummerBC136800
Gene symbol B7H6
Gene ID (NCBI) 374383
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

B7-H6, also known as NCR3LG1, is a member of the B7 family of immunoreceptors. It is a 454-aa-long type I transmembrane protein consisting of an extracellular region, a transmembrane segment, and a cytoplasmic domain which contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), an SH2-binding domain, and an SH3-binding motif. B7-H6 triggers NKp30-mediated activation of human NK cells (PMID: 19528259). It has been reported that B7H6 is expressed in various types of tumor cells and plays a prominent role in natural killer cell immunosurveillance (PMID: 35697295). The apparent molecular weight of B7-H6 is larger than the calculated molecular weight of 51 kDa due to glycosylation (PMID: 19528259).