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BAG2 Rekombinanter Antikörper

BAG2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242717G4

Kat-Nr. : 85063-4-PBS

Synonyme

242717G4, BAG-2, KIAA0576

Filter:
  • Western Blot (WB) analysis of various lysates using BAG2 Recombinant antibody (85063-4-RR)

    WB analysis using 85063-4-RR (same clone as 85063-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85063-4-RR (BAG2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85063-4-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using BAG2 Recombinant antibody (85063-4-RR)

    WB analysis using 85063-4-RR (same clone as 85063-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85063-4-RR (BAG2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85063-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85063-4-RR

    Affinity and Kinetic Characterization of 85063-4-RR

    Biolayer interferometry (BLl) kinetic assays of 85063-4-RR against Human BAG2 were performed. The affinity constant is 0.644 nM.

Geprüfte Anwendungen

Produktinformation

85063-4-PBS bindet in WB, Indirect ELISA BAG2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen BAG2 fusion protein Ag30873
Vollständiger Name BCL2-associated athanogene 2
Berechnetes Molekulargewicht 24 kDa
Beobachtetes Molekulargewicht25 kDa
GenBank-ZugangsnummerNM_004282
Gene symbol BAG2
Gene ID (NCBI) 9532
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

BAG2 (BAG family molecular chaperone regulator 2) is one of six proteins in mammals that contain the BAG domain, which belongs to the BAG (Bcl-2-associated athanogene) family. BAG2 has been described as a negative regulator of the chaperone-associated ubiquitin ligase C terminus of Hsc70-interacting protein (CHIP) that participates in the ubiquitin-mediated proteasomal degradation of misfolded substrate proteins (PMID: 16207813). BAG2 is widely expressed in human tissues, including brown adipose, heart and lung tissue, as well as in various types of tumor cells, including renal cell carcinoma, glioblastoma and thyroid carcinoma cells (PMID: 28536620). BAG2 overexpression is associated with poor prognosis in patients and mutp53 accumulation in tumors (PMID: 26271008).