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BCAM Polyklonaler Antikörper

BCAM Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33665-1-PBS

Synonyme

Basal cell adhesion molecule, B-CAM cell surface glycoprotein, CD239, Gplu, Lu

Filter:
  • Western Blot (WB) analysis of various lysates using BCAM Polyclonal antibody (33665-1-AP)

    WB analysis using 33665-1-AP (same clone as 33665-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33665-1-AP (BCAM antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33665-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

33665-1-PBS bindet in WB, Indirect ELISA BCAM und zeigt Reaktivität mit Maus, Ratten

Getestete Reaktivität Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen BCAM fusion protein Eg6306
Vollständiger Name basal cell adhesion molecule
Berechnetes Molekulargewicht68 kDa
Beobachtetes Molekulargewicht67 kDa, 78-85 kDa
GenBank-ZugangsnummerNM_020486.2
Gene symbol Bcam
Gene ID (NCBI) 57278
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Basal cell adhesion molecule (Lu/BCAM) is a membrane-bound glycoprotein of the immunoglobulin superfamily (IgSF), functioning as a receptor for the extracellular matrix protein, laminin. BCAM (Lutheran/basal cell-adhesion molecule, a glycoprotein) belongs to the immunoglobulin superfamily which contains both Lu blood group and BCAM tumor-associated antigens. Proteomics analysis suggests that BCAM might be a potential biomarker for pancreatic cancer (PMID: 19199705). BCAM, involved in cell adhesion and migration, can also promote tumor metastasis and has been elucidated to play a functional role in the metastasis of thyroid cancer and gastric cancer (PMID: 10728810, 35941663). De-glycosylated BCAM has a preidicted molecular weight of 67 kDa. Two BCAM glycoprotein (gp) isoforms are present on human RBCs, Lu (85 kDa) and Lu(v13) (78 kDa); they result from the alternative splicing of intron 13 and differ by the lengths of their cytoplasmic domains (PMID: 23160466).