BCAS3 Polyklonaler Antikörper

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BCAS3 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 10402-1-PBS

Synonyme

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  WB analysis using 10402-1-AP (same clone as 10402-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 10402-1-AP (BCAS3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10402-1-PBS in a different storage buffer formulation.

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  WB analysis of A431 using 10402-1-AP (same clone as 10402-1-PBS)

  WB result of BCAS3 antibody (10402-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-BCAS3 transfected A431 cells. This data was developed using the same antibody clone with 10402-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

10402-1-PBS bindet in WB, Indirect ELISA BCAS3 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: BCAS3 fusion protein Ag0646
• Vollständiger Name: breast carcinoma amplified sequence 3
• Berechnetes Molekulargewicht: 99 kDa
• Beobachtetes Molekulargewicht: 74 kDa
• GenBank-Zugangsnummer: BC001250
• Gene symbol: BCAS3
• Gene ID (NCBI): 54828
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Rudhira/BCAS3 (Breast Cancer Amplified Sequence 3) is a conserved protein expressed in the embryonic vasculature and malignant tumors. Rudhira is a predicted WD40 domain protein. During mouse development Rudhira is expressed in erythropoietic and angiogenic precursors but not in their differentiated progeny. This transient expression of Rudhira is also seen in normal adult angiogenesis. BCAS3, the human ortholog of Rudhira is 98% identical and the gene maps to a breakpoint of hematological neoplasms on chromosome 17q23.1. BCAS3 is also expressed in vascular development in embryoid bodies in vitro and was originally identified as a gene over-expressed in breast cancers. It is reported to be a target of metastasis associated protein-1 (MTA-1). Further BCAS3 expression is also upregulated in grade III and IV glioblastomas where it is misexpressed in the tumor cells.

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