BCL11A Polyklonaler Antikörper

BCL11A Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11613-1-PBS

Synonyme

B cell lymphoma/leukaemia 11A, B-cell CLL/lymphoma 11A, B-cell lymphoma/leukemia 11A, BCL-11A, COUP-TF-interacting protein 1

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  WB analysis using 11613-1-AP (same clone as 11613-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 11613-1-AP (BCL11A antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 11613-1-AP (same clone as 11613-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 11613-1-AP (same clone as 11613-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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  IHC staining of human gliomas using 11613-1-AP (same clone as 11613-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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  IHC staining of human gliomas using 11613-1-AP (same clone as 11613-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse spleen using 11613-1-AP (same clone as 11613-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11613-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

11613-1-PBS bindet in WB, IHC, Indirect ELISA BCL11A und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: BCL11A fusion protein Ag2187
• Vollständiger Name: B-cell CLL/lymphoma 11A (zinc finger protein)
• Berechnetes Molekulargewicht: 835 aa, 91 kDa
• GenBank-Zugangsnummer: BC021098
• Gene symbol: BCL11A
• Gene ID (NCBI): 53335
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

B-CELL CLL/LYMPHOMA 11A(BCL11A)is a highly conserved zinc finger gene. It acts as a myeloid and B-cell proto-oncogene, and may play key roles in leukemogenesis and hematopoiesis. It is an essential factor in lymphopoiesis, and required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. It is also involved in lymphoid malignancies through translocation or amplification events. It has recently been shown that BCL11A expression is inversely correlated with γ globin expression.(PMID:21156846). This is a rabbit polyclonal antibody raised against part chain of N-terminal BCL11A of human origin. There are three isoforms of BCL11A: isoform1(773aa), isoform2(486aa) and isoform3(239aa)