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BCL2 Monoklonaler Antikörper
BCL2 Monoklonal Antikörper für IHC, IF/ICC, IF-P, IP, Cytometric bead array, Indirect ELISA
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
Hausschwein, human
Anwendung
IHC, IF/ICC, IF-P, IP, Cytometric bead array, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
4H8C6
Kat-Nr. : 60178-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
60178-1-PBS bindet in IHC, IF/ICC, IF-P, IP, Cytometric bead array, Indirect ELISA BCL2 und zeigt Reaktivität mit Hausschwein, human
Getestete Reaktivität | Hausschwein, human |
Wirt / Isotyp | Maus / IgG2b |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | BCL2 fusion protein Ag3508 |
Vollständiger Name | B-cell CLL/lymphoma 2 |
Berechnetes Molekulargewicht | 26 kDa |
Beobachtetes Molekulargewicht | 26 kDa |
GenBank-Zugangsnummer | BC027258 |
Gene symbol | BCL2 |
Gene ID (NCBI) | 596 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
1) What is Bcl-2?
Bcl-2 (B-cell lymphoma 2) is an outer mitochondrial membrane protein that via heterodimerization with BAX proteins controls apoptosis. Abnormalities of Bcl-2 activity can lead to cancer, autoimmune diseases, and schizophrenia.2) FAQs for Bcl-2
A) How to measure Bcl-2 and Bax apoptotic markers by western blotting
Generally, Bcl-2 protein is considered to have anti-apoptotic activity, while Bax has apoptotic activity. Comparing the ratio between Bcl-2 and Bax protein levels in different samples or cells subjected to treatments can reflect the apoptotic state of the cells. Expression of Bax can vary between cell lines and it is important to compare it to Bcl-2 levels.
B) What band size should I expect in western blotting for Bcl-2?
The molecular weight of Bcl-2 is 26 kDa.