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BCMA/TNFRSF17 Rekombinanter Antikörper

BCMA/TNFRSF17 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241731A11

Kat-Nr. : 98215-1-PBS

Synonyme

TNFRSF17, CD269, BCMA, BCM, B-cell maturation protein

Filter:
  • Flow cytometry (FC) experiment of U266 cells using Anti-Human BCMA/TNFRSF17 Rabbit Recombinant Antibo (98215-1-RR)

    FC experiment of U266 using 98215-1-RR (same clone as 98215-1-PBS)

    1x10^6 U266 cells (left) or HEK-293T (right) were surface stained with 0.25 ug Anti-Human BCMA/TNFRSF17 Rabbit Recombinant Antibody (98215-1-RR, Clone: 241731A11) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98215-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98215-1-RR

    Affinity and Kinetic Characterization of 98215-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98215-1-RR against Human BCMA/TNFRSF17 were performed. The affinity constant is 0.20 nM.

Geprüfte Anwendungen

Produktinformation

98215-1-PBS bindet in FC BCMA/TNFRSF17 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name tumor necrosis factor receptor superfamily, member 17
Berechnetes Molekulargewicht 184 aa, 20 kDa
GenBank-ZugangsnummerBC058291
Gene symbol TNFRSF17
Gene ID (NCBI) 608
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

BCMA (B cell maturation antigen), also known as TNFRSF17, is 20.2-kDa type III transmembrane glycoprotein and is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and plasma cells, which may be important for B cell development and autoimmune response (PMID: 32943087; 9846698). BCMA has two agonist ligands: a proliferation-inducing ligand (APRIL) and BAFF. When BCMA binds to APRIL, it transmits signals of cell survival and proliferation (PMID: 27127303); when BCMA binds to BAFF, it mediates the activation of NF-kappaB and MAPK8/JNK (PMID: 36140254). It has been found that the overexpression and activation of BCMA are associated with multiple myeloma (MM) in preclinical models and humans, supporting its potential utility as a therapeutic target for MM (PMID: 32055000; 32943087).