BCMA/TNFRSF17 Rekombinanter Antikörper

BCMA/TNFRSF17 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241731A11

Kat-Nr. : 98215-1-RR

Synonyme

TNFRSF17, CD269, BCMA, BCM, B-cell maturation protein

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  FC experiment of U266 using 98215-1-RR

  1x10^6 U266 cells (left) or HEK-293T (right) were surface stained with 0.25 ug Anti-Human BCMA/TNFRSF17 Rabbit Recombinant Antibody (98215-1-RR, Clone: 241731A11) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98215-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98215-1-RR against Human BCMA/TNFRSF17 were performed. The affinity constant is 0.20 nM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: U266 cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98215-1-RR bindet in FC BCMA/TNFRSF17 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 17
• Berechnetes Molekulargewicht: 184 aa, 20 kDa
• GenBank-Zugangsnummer: BC058291
• Gene symbol: TNFRSF17
• Gene ID (NCBI): 608
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

BCMA (B cell maturation antigen), also known as TNFRSF17, is 20.2-kDa type III transmembrane glycoprotein and is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and plasma cells, which may be important for B cell development and autoimmune response (PMID: 32943087; 9846698). BCMA has two agonist ligands: a proliferation-inducing ligand (APRIL) and BAFF. When BCMA binds to APRIL, it transmits signals of cell survival and proliferation (PMID: 27127303); when BCMA binds to BAFF, it mediates the activation of NF-kappaB and MAPK8/JNK (PMID: 36140254). It has been found that the overexpression and activation of BCMA are associated with multiple myeloma (MM) in preclinical models and humans, supporting its potential utility as a therapeutic target for MM (PMID: 32055000; 32943087).