BDNF Monoklonaler Antikörper
BDNF Monoklonal Antikörper für WB, IF/ICC, Indirect ELISA
Wirt / Isotyp
Maus / IgG2a
Getestete Reaktivität
human
Anwendung
WB, IF/ICC, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
1E5C5
Kat-Nr. : 66292-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
66292-1-PBS bindet in WB, IF/ICC, Indirect ELISA BDNF und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Maus / IgG2a |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | BDNF fusion protein Ag11329 |
Vollständiger Name | brain-derived neurotrophic factor |
Berechnetes Molekulargewicht | 247 aa, 28 kDa |
Beobachtetes Molekulargewicht | 32 kDa |
GenBank-Zugangsnummer | BC029795 |
Gene symbol | BDNF |
Gene ID (NCBI) | 627 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
1) What is BDNF?
BDNF (brain-derived neurotrophic factor) is a small secreted growth factor that is important for the development and plasticity of the central nervous system and vital for long-term memory. Selected polymorphisms of BDNF have been shown to increase susceptibility to memory impairment and selected eating and mental disorders.
2) FAQs for BDNF
A) I can detect more than one band in my samples
BDNF is a neurotrophin that is a subject of maturation by proteolytic cleavage. The precursor protein (pre-proBDNF) is first cleaved to proBDNF (~34 kDa) by removing a signal peptide, and then to a mature form of BDNF (14 kDa). Additionally, (pre-)proBDNF can form dimers that run between 50 and 60 kDa, and a minor truncated form of proBDNF running at 28 kDa has also been reported (PMID: 11152678).