BEX1/2 Polyklonaler Antikörper

BEX1/2 Polyklonal Antikörper für WB, IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (1)

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen(6)

Rezensionen (1)

Kat-Nr. : 12390-1-AP

Synonyme

BEX1, BEX1/2, BEX2, brain expressed X linked 2, hBex2, Protein BEX2

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• 

  WB analysis of human brain using 12390-1-AP

  human brain tissue were subjected to SDS PAGE followed by western blot with 12390-1-AP (BEX1/2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  IHC staining of human medulloblastoma using 12390-1-AP

  Immunohistochemical analysis of paraffin-embedded human medulloblastoma using 12390-1-AP (BEX1/2 antibody) at dilution of 1:100 (under 10x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: humanes Hirngewebe
• Erfolgreiche Detektion in IHC: humanes Medulloblastom-Gewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:1000
• Immunhistochemie (IHC): IHC : 1:20-1:200

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 4 publications below
• IHC: See 1 publications below
• IF: See 2 publications below

Produktinformation

12390-1-AP bindet in WB, IHC, IF, ELISA BEX1/2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: BEX1/2 fusion protein Ag3066
• Vollständiger Name: brain expressed X-linked 2
• Berechnetes Molekulargewicht: 128 aa, 15 kDa
• Beobachtetes Molekulargewicht: 10-15 kDa
• GenBank-Zugangsnummer: BC015522
• Gene symbol: BEX2
• Gene ID (NCBI): 84707
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

BEX1 is a signaling adapter molecule involved in p75NTR/NGFR signaling. It lays a role in cell cycle progression and neuronal differentiation. BEX1 inhibits neuronal differentiation in response to nerve growth factor (NGF). BEX2 is a regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. It regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity. The homology between human BEX1 and BEX2 is 94%. This antibody detects both BEX1 and BEX2.

Publikationen

Species	Application	Title
human,mouse	IF	BMC Biol; Bex1 is essential for ciliogenesis and harbours biomolecular condensate-forming capacity.; Authors - Emi Hibino
human	WB	Int J Biol Sci; BEX2 promotes tumor proliferation in colorectal cancer.; Authors - Yeting Hu
human	WB	Front Cell Dev Biol; Single-cell and genetic multi-omics analysis combined with experiments confirmed the signature and potential targets of cuproptosis in hepatocellular carcinoma; Authors - Feng Cao
human,mouse	IHC,IF	Cell Death Dis; Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells; Authors - Ning Mu
human	WB	Aging (Albany NY); Machine learning-based identification and immune characterization of ferroptosis-related molecular clusters in osteoarthritis and validation; Authors - Xiaocheng Guo
human	WB	Transl Oncol; LMO2 confers value as a potential immunotherapy marker in pan-cancer analysis and inhibits progression of Clear Cell Renal Cell Carcinoma; Authors - Huiping Wang

Rezensionen

The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.

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FH

Kamal (Verified Customer) (02-15-2024)

This antibody works for mouse liver tissue when diluted in 1X TBST.

• Applications: Western Blot
• Primary Antibody Dilution: 1:1000
• Cell Tissue Type: Mouse liver tissue