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BMP2K Polyklonaler Antikörper

BMP2K Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32853-1-PBS

Synonyme

BIKe, BMP-2-inducible protein kinase, EC:2.7.11.1, HRIHFB2017

Filter:
  • Western Blot (WB) analysis of various lysates using BMP2K Polyclonal antibody (32853-1-AP)

    WB analysis using 32853-1-AP (same clone as 32853-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 32853-1-AP (BMP2K antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32853-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

32853-1-PBS bindet in WB, Indirect ELISA BMP2K und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen BMP2K fusion protein Ag36482
Vollständiger Name BMP2 inducible kinase
Berechnetes Molekulargewicht129kDa，1161aa
Beobachtetes Molekulargewicht140 kDa
GenBank-ZugangsnummerNM_198892.1
Gene symbol BMP2K
Gene ID (NCBI) 55589
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

BMP2K is an uncharacterized member of NAK family. Structural similarities of kinase domains (75% identical) and in vitro inhibition profiles categorized BMP2K as the closest homolog of AAK1. BMP2K was originally identified as a serine-threonine kinase regulating osteoblast differentiation whose gene product is sharply upregulated by BMP-2 stimulation. Later, various genetic and proteomic screens linked BMP2K to HIV entry, developmental dysplasia of the hip, myopia, leukemia, breast cancer metastasis and so on. Recent multivariate proteomic profiling approaches identified BMP2K as a component of purified CCV from HeLa cells. BMP2K can phosphorylate AP-2 in vitro and in vivo. Functional impairment of BMP2K impedes AP-2 phosphorylation leading to defects in clathrin-coated pit (CCP) morphology and cargo internalization. BMP2K engages AP-2 via its extended C-terminus and this interaction is important for its CCP localization and function (PMID: 34480404).