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BRWD3 Polyklonaler Antikörper

BRWD3 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31795-1-PBS

Synonyme

Bromodomain and WD repeat-containing protein 3

Filter:
  • Western Blot (WB) analysis of various lysates using BRWD3 Polyclonal antibody (31795-1-AP)

    WB analysis using 31795-1-AP (same clone as 31795-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31795-1-AP (BRWD3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31795-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

31795-1-PBS bindet in WB, Indirect ELISA BRWD3 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen BRWD3 fusion protein Ag36948
Vollständiger Name bromodomain and WD repeat domain containing 3
Berechnetes Molekulargewicht204 kDa
Beobachtetes Molekulargewicht240 kDa
GenBank-ZugangsnummerBC039508
Gene symbol BRWD3
Gene ID (NCBI) 254065
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Bromodomain and WD repeat-containing protein 3 (BRWD3) is thought to regulate gene expression through its interactions with chromatin. BRWD3 promotes the K48-linked polyubiquitination and degradation of KDM5, which depends on BRWD3 and Cul4. This function is critical for maintaining H3K4 methylation levels and regulating gene expression (PMID: 37722046). Mutations of BRWD3 are associated with a spectrum of cognitive disabilities and X-linked macrocephaly (PMID: 17668385).