BST2 Rekombinanter Antikörper

BST2 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250317H5

Kat-Nr. : 98305-2-PBS

Synonyme

CD317, Bone marrow stromal antigen 2, BST 2, BST-2, CD 317

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  FC experiment of human PBMCs using 98305-2-RR (same clone as 98305-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human BST2 Rabbit RecAb (98305-2-RR, Clone: 250317H5) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD14. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98305-2-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98305-2-RR (same clone as 98305-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human BST2 Rabbit RecAb (98305-2-RR, Clone: 250317H5) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98305-2-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98305-2-PBS bindet in FC BST2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: BST2 fusion protein Eg1961
• Vollständiger Name: bone marrow stromal cell antigen 2
• Berechnetes Molekulargewicht: 180 aa, 20 kDa
• GenBank-Zugangsnummer: BC033873
• Gene symbol: BST2
• Gene ID (NCBI): 684
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

BST2, also named as CD317 and Tetherin, belongs to the tetherin family. It may be involved in the sorting of secreted proteins and it is involved in pre-B-cell growth. BST2 is an antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. BST2 may play a role in B-cell activation in rheumatoid arthritis. It is recently identified interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. BST2 is a plasma membrane proteins, tetherin inhibits virion particle release from infected cells. BST2 is effective against retroviruses and flavoviruses whilst IFITMs disrupt influenza and flavivirus infection. Observed MW of BST2 is 30-36 kDa (PMID: 19196977; 21237475).