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C1orf112 Polyklonaler Antikörper

C1orf112 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 27863-1-PBS

Synonyme

APOLO1, FIDGETIN-like-1 interacting protein, FIGNL1 Interacting Regulator Of Recombination And Mitosis, FIGNL1-interacting regulator of recombination and mitosis, FIRRM

Filter:
  • Western Blot (WB) analysis of various lysates using C1orf112 Polyclonal antibody (27863-1-AP)

    WB analysis using 27863-1-AP (same clone as 27863-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27863-1-AP (C1orf112 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27863-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

27863-1-PBS bindet in WB, Indirect ELISA C1orf112 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen C1orf112 fusion protein Ag27316
Vollständiger Name chromosome 1 open reading frame 112
Berechnetes Molekulargewicht 853 aa, 97 kDa
Beobachtetes Molekulargewicht98 kDa
GenBank-ZugangsnummerBC107168
Gene symbol C1orf112
Gene ID (NCBI) 55732
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FIRRM (Fanconi anemia pathway and RAD51-mediated DNA repair regulator, also known as C1orf112 or FLIP) is an evolutionarily conserved protein involved in DNA damage repair and homologous recombination. It ensures DNA cross-link (ICL) repair and genomic stability by regulating RAD51 activity. FIRRM expression is upregulated in a variety of tumors and correlates with poor prognosis. Its dysfunction leads to increased genomic instability, as evidenced by enhanced DNA damage signaling, chromosomal abnormalities, and micronucleus formation. The study of FIRRM is important for understanding the mechanisms of tumorigenesis and developing new therapeutic strategies.