CALCR Polyklonaler Antikörper

CALCR Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen(6)

Kat-Nr. : 20868-1-AP

Synonyme

calcitonin receptor, CRT, CT R, CTR, CT-R

---

• 

  WB analysis using 20868-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 20868-1-AP (CALCR antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

---

Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: MCF-7-Zellen, Maushirngewebe, Mausnierengewebe, PC-12-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 6 publications below

Produktinformation

20868-1-AP bindet in WB, ELISA CALCR und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CALCR fusion protein Ag14920
• Vollständiger Name: calcitonin receptor
• Berechnetes Molekulargewicht: 490 aa, 57 kDa
• Beobachtetes Molekulargewicht: 70 kDa
• GenBank-Zugangsnummer: BC075028
• Gene symbol: CALCR
• Gene ID (NCBI): 799
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The CALCR protein, also known as the calcitonin receptor, is a high-affinity receptor for the peptide hormone calcitonin and belongs to the subfamily of seven transmembrane-spanning G protein-coupled receptors. This protein plays a critical role in maintaining calcium homeostasis and regulating osteoclast-mediated bone resorption. The calcitonin receptor is involved in several physiological processes, including inhibition of osteoclastic bone resorption and increased renal calcium excretion, which helps to regulate Ca2+ concentrations. In addition, the CALCR protein has been detected in a variety of tissues not directly involved in the regulation of calcium homeostasis, with particular expression observed in the brain, suggesting distinct functions in the central nervous system (CNS) (PMID: 12730726).

Publikationen

Species	Application	Title
	WB	J Cell Mol Med; Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis.; Authors - Zhi Qian
human	WB	Mol Med; A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone.; Authors - Yu Fu
human	WB	Curr Issues Mol Biol; COPS5 Conferred the Platinum Resistance in Epithelial Ovarian Cancer; Authors - Ming-Wei Lin
human	WB	Adv Sci (Weinh); Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening.; Authors - Fangyuan Shao
mouse	WB	Nat Commun; Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics; Authors - Xi Shao
mouse	WB	Cell Metab; Gut microbial alterations in arginine metabolism determine bone mechanical adaptation; Authors - Dan Wang