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CAMSAP1 Polyklonaler Antikörper

CAMSAP1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 18816-1-PBS

Synonyme

PRO2405, Calmodulin-regulated spectrin-associated protein 1

Filter:
  • Western Blot (WB) analysis of various lysates using CAMSAP1 Polyclonal antibody (18816-1-AP)

    WB analysis using 18816-1-AP (same clone as 18816-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 18816-1-AP (CAMSAP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18816-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

18816-1-PBS bindet in WB, Indirect ELISA CAMSAP1 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name calmodulin regulated spectrin-associated protein 1
Berechnetes Molekulargewicht 179 kDa
Beobachtetes Molekulargewicht245 kDa
GenBank-ZugangsnummerBC144082
Gene symbol CAMSAP1
Gene ID (NCBI) 157922
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CAMSAP1, or Calmodulin-regulated spectrin-associated protein 1, is a protein that plays a crucial role in the formation and maintenance of the minus end of non-centrosomal microtubules, which are essential for proper neuronal function and development. Research has shown that CAMSAP1 is vital for neuronal polarization, migration, and cortical lamination. CAMSAP1 has also been implicated in cancer prognosis. A study found that CAMSAP1 mutation can activate anti-tumor immunity, mediate tumor cell apoptosis, inhibit epithelial-mesenchymal transition (EMT), improve prognosis, and improve platinum drug sensitivity in small-cell lung cancer patients treated with platinum-based chemotherapy, suggesting that CAMSAP1 mutation may be a potential biomarker indicating platinum drug sensitivity and patient prognosis. The CAMSAP1 of the calculated MW is around 170 kDa, and the observed MW is 245 kDa (PMID: 32839317).