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Caspase 14 Polyklonaler Antikörper

Caspase 14 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 28136-1-PBS

Synonyme

CASP14, CASP 14, Caspase-14 subunit p10, mature form, Caspase-14, Caspase14

Filter:
  • Western Blot (WB) analysis of various lysates using Caspase 14 Polyclonal antibody (28136-1-AP)

    WB analysis using 28136-1-AP (same clone as 28136-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28136-1-AP (Caspase 14 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28136-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

28136-1-PBS bindet in WB, Indirect ELISA Caspase 14 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Caspase 14 fusion protein Ag27242
Vollständiger Name caspase 14, apoptosis-related cysteine peptidase
Berechnetes Molekulargewicht 242 aa, 28 kDa
Beobachtetes Molekulargewicht35 kDa
GenBank-ZugangsnummerBC069541
Gene symbol CASP14
Gene ID (NCBI) 23581
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Caspase14 belongs to the caspase family of cysteinyl aspartate-specific proteinases that frequently play a central role in apoptosis. Caspase14 exist as inactive proenzymes that undergo proteolytic processing to produce large and small subunits (p20 and p10) at Ile152/Lys153 residues, which is different to other caspases (Asp residue). Caspase14 plays a role in protein maturation of filaggrin, and possibly in DNA repair. Overexpression of Caspase14 has been detected in several of epithelial malignancies, indicating that Caspase14 could play a role in carcinogenesis and disease progression of cancers. Caspase14 can binds the apoptosis-inducing factor (AIF) indicating that caspase14 may be an anti-apoptotic protein. In the LADC specimens, two bands can be detected with MW of 35 kDa and 37 kDa which represent Caspase14 and the phosphorylated Caspase14(pCasp-14) respectively. (PMID:21567094, 12200134, 10203698, 17515931, 16061209). This antibody can recognise all the forms of Caspase14.