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CASR Rekombinanter Antikörper

CASR Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

243029B11

Kat-Nr. : 86319-1-PBS

Synonyme

Calcium Sensing Receptor, CAR, Extracellular calcium-sensing receptor, FHH, FIH

Filter:
  • Western Blot (WB) analysis of various lysates using CASR Recombinant antibody (86319-1-RR)

    WB analysis using 86319-1-RR (same clone as 86319-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86319-1-RR (CASR antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86319-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86319-1-PBS bindet in WB, Indirect ELISA CASR und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name calcium-sensing receptor
Berechnetes Molekulargewicht 121 kDa
Beobachtetes Molekulargewicht120 kDa
GenBank-ZugangsnummerNM_000388
Gene symbol Calcium Sensing Receptor
Gene ID (NCBI) 846
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CASR, also named as GPRC2A, PCAR1, belongs to the G-protein coupled receptor 3 family. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. The activity of CASR is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. It has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).