CATSPER1 Polyklonaler Antikörper

CATSPER1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12722-1-PBS

Synonyme

Cation channel sperm-associated protein 1, CATSPER, hCatSper

---

• 

  WB analysis using 12722-1-AP (same clone as 12722-1-PBS)

  human testis lysates were subjected to SDS PAGE followed by western blot with 12722-1-AP (CATSPER1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12722-1-PBS in a different storage buffer formulation.

---

Geprüfte Anwendungen

Produktinformation

12722-1-PBS bindet in WB, Indirect ELISA CATSPER1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CATSPER1 fusion protein Ag3417
• Vollständiger Name: cation channel, sperm associated 1
• Berechnetes Molekulargewicht: 780 aa, 90 kDa
• Beobachtetes Molekulargewicht: 90 kDa
• GenBank-Zugangsnummer: BC032950
• Gene symbol: CATSPER1
• Gene ID (NCBI): 117144
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Cation channel sperm-associated protein 1 (CATSPER1) belongs to a family of four sperm-specific tetrameric voltage-gated cation channels that are highly conserved in humans and mice (PMID: 12402840; 12932298). Definitive evidence that CatSper1 functions as a voltage-gated calcium channel to facilitate hyperactivated sperm motility came from whole-cell patch-clamp measurements of spermatozoa (PMID: 16467839). CATSPER1 channel currents were potentiated in response to intracellular alkalinization, increasing the concentration of intraflagellar calcium and thereby inducing hyperactivity.