CBX2 Polyklonaler Antikörper

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• KD/KO Validated

CBX2 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

6

Kat-Nr. : 15579-1-AP

Synonyme

CBX2, CDCA6, Chromobox protein homolog 2, M33

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Galerie der Validierungsdaten

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  WB analysis using 15579-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 15579-1-AP (CBX2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 15579-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 15579-1-AP (CBX2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 15579-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 15579-1-AP (CBX2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HEK-293-Zellen, HeLa-Zellen, Mausherzgewebe, MCF-7-Zellen, Rattenherzgewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:8000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 3 publications below
• WB: See 6 publications below
• IHC: See 2 publications below
• IF: See 1 publications below

Produktinformation

15579-1-AP bindet in WB, IHC, IF, ELISA CBX2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CBX2 fusion protein Ag7979
• Vollständiger Name: chromobox homolog 2 (Pc class homolog, Drosophila)
• Berechnetes Molekulargewicht: 56 kDa
• Beobachtetes Molekulargewicht: 65-70 kDa
• GenBank-Zugangsnummer: BC004252
• Gene symbol: CBX2
• Gene ID (NCBI): 84733
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The chromobox homologue protein 2 (CBX2) is a critical component of the PRC1 complex involved in antiviral innate immunity, neuronal, and gonadal differentiation, axial patterning during embryonic development, cell proliferation, and senescence (PMID: 32870972). CBX2 has 2 isoforms with the molecular mass of 23 and 56 kDa. Sometimes higher molecular weight around 65-70 kDa can also be observed, which may be a modified variant of CBX2.

Publikationen

Species	Application	Title
human	WB	Cell; Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.; Authors - Xun Huang ; KD Validated
human	WB,IHC	Am J Transl Res; Overexpression of CBX2 in breast cancer promotes tumor progression through the PI3K/AKT signaling pathway.; Authors - Shipeng Zheng ; KD Validated
human	WB,IHC,IF	Mol Carcinog; Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells; Authors - Yujia Ma ; KD Validated
mouse	WB	Cell Rep; SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions; Authors - Haining Zhou
human	WB	Oncol Lett; Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis; Authors - Xuan Meng
human	WB	Heliyon; Derepressing of STAT3 and USP7 contributes to resistance of DLBCL to EZH2 inhibition; Authors - Chenyun He