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CCDC88A Polyklonaler Antikörper

CCDC88A Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33569-1-PBS

Synonyme

Akt phosphorylation enhancer, APE, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, Girders of actin filament

Filter:
  • Western Blot (WB) analysis of various lysates using CCDC88A Polyclonal antibody (33569-1-AP)

    WB analysis using 33569-1-AP (same clone as 33569-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33569-1-AP (CCDC88A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33569-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

33569-1-PBS bindet in WB, Indirect ELISA CCDC88A und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen CCDC88A fusion protein Ag37983
Vollständiger Name coiled-coil domain containing 88A
Beobachtetes Molekulargewicht220 kDa
GenBank-ZugangsnummerBC132736
Gene symbol CCDC88A
Gene ID (NCBI) 55704
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CCDC88A, also named as APE, GRDN and KIAA1212, belongs to the CCDC88 family. CCDC88A enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby it induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation CCDC88A is essential for the integrity of the actin cytoskeleton and for cell migration. It is required for formation of actin stress fibers and lamellipodia. It may be involved in membrane sorting in the early endosome.