CCL17/TARC Polyklonaler Antikörper

CCL17/TARC Polyklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IHC, ELISA

Konjugation

Unkonjugiert

Publikationen(2)

Kat-Nr. : 22342-1-AP

Synonyme

CCL17, TARC, CCL-17, CCL 17, C-C motif chemokine 17

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  IHC staining of human colon using 22342-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 22342-1-AP (CCL17 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human colon using 22342-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 22342-1-AP (CCL17 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human placenta using 22342-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 22342-1-AP (CCL17 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human placenta using 22342-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 22342-1-AP (CCL17 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human colon cancer using 22342-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 22342-1-AP (CCL17 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human colon cancer using 22342-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 22342-1-AP (CCL17 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Kolongewebe, humanes Kolonkarzinomgewebe, humanes Plazenta-Gewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• IHC: See 2 publications below

Produktinformation

22342-1-AP bindet in IHC, ELISA CCL17/TARC und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CCL17/TARC fusion protein Ag17832
• Vollständiger Name: chemokine (C-C motif) ligand 17
• Berechnetes Molekulargewicht: 94 aa, 11 kDa
• GenBank-Zugangsnummer: BC112066
• Gene symbol: CCL17
• Gene ID (NCBI): 6361
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CCL17, also named as TARC, is a member of the CC chemokine family, and is highly expressed by thymus and other cells, including keratinocytes, endothelial cells, dendritic cells, bronchial epithelial cells and fibroblasts. CCL17 plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. CCL17 induced chemotaxis and Ca2+ influx in the cells stably expressing CCR4, thereby demonstrating the ligand-receptor relationship between CCL17 and CCR4.

Publikationen

Species	Application	Title
human	IHC	Br J Haematol; Expression of multiple cytokines and chemokine receptor 4 in angioimmunoblastic T-cell lymphoma with abundant plasma cell infiltration involving the skin.; Authors - Shoko Nakayama
human	IHC	Hemasphere; NOTCH1 fusions in pediatric T-cell lymphoblastic lymphoma: A high-risk subgroup with CCL17 (TARC) levels as diagnostic biomarker; Authors - Emma Kroeze