CCL22/MDC Rekombinanter Antikörper
CCL22/MDC Rekombinant Antikörper für Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus
Anwendung
Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
241668C10
Kat-Nr. : 84370-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
84370-1-PBS bindet in Indirect ELISA CCL22/MDC und zeigt Reaktivität mit human, Maus
| Getestete Reaktivität | human, Maus |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Rekombinant |
| Typ | Antikörper |
| Immunogen | CCL22/MDC fusion protein Eg1974 |
| Vollständiger Name | chemokine (C-C motif) ligand 22 |
| Berechnetes Molekulargewicht | 93 aa, 11 kDa |
| GenBank-Zugangsnummer | BC027952 |
| Gene symbol | CCL22/MDC |
| Gene ID (NCBI) | 6367 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS only |
| Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
CCL22, also known as macrophage-derived chemokine (MDC), is a member of the CC chemokine family. It is primarily produced by myeloid cells such as macrophages and dendritic cells (DCs) under steady-state conditions. CCL22 plays a significant role in immune responses by regulating the migration of different subsets of leukocytes. It shares the same receptor, CCR4, which is predominantly expressed by Th2 cells, making CCL22 a key mediator in the development of Th2-dominant diseases such as atopic dermatitis and asthma. Elevated serum levels of CCL22 are observed in patients with these conditions. CCL22 is also expressed in several types of tumor cells and Foxp3+ regulatory T cells (Tregs), suggesting its involvement in attracting Tregs into the tumor microenvironment to evade immune attacks.
