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CCNK Polyklonaler Antikörper

CCNK Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 26933-1-PBS

Synonyme

Cyclin K, CPR4, Cyclin-K

Filter:
  • Western Blot (WB) analysis of various lysates using CCNK Polyclonal antibody (26933-1-AP)

    WB analysis using 26933-1-AP (same clone as 26933-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 26933-1-AP (CCNK antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26933-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse brain tissue using CCNK Polyclonal antibody (26933-1-AP)

    IHC staining of mouse brain using 26933-1-AP (same clone as 26933-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 26933-1-AP (CCNK antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26933-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

26933-1-PBS bindet in WB, IHC, Indirect ELISA CCNK und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen CCNK fusion protein Ag25556
Vollständiger Name cyclin K
Berechnetes Molekulargewicht 64 kDa
Beobachtetes Molekulargewicht 70 kDa
GenBank-ZugangsnummerBC015935
Gene symbol CCNK
Gene ID (NCBI) 8812
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Cyclin-K (CCNK) is also named as CPR4 and belongs to the cyclin family. CCNK is a regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases (PMID:10574912). It plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A) (PMID:9632813). The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes (PMID:22012619).