CCR6 Monoklonaler Antikörper

CCR6 Monoklonal Antikörper für IHC, IF/ICC, IF-P, ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

IHC, IF/ICC, IF-P, ELISA

Konjugation

Unkonjugiert

CloneNo.

1C11A9

Kat-Nr. : 66801-1-PBS

Synonyme

1C11A9, BN 1, C C chemokine receptor type 6, C C CKR 6, C-C chemokine receptor type 6

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  IHC staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66801-1-Ig (CCR6 antibody) at dilution of 1:500 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66801-1-Ig (CCR6 antibody) at dilution of 1:500 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

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  IF Staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CCR6 antibody (66801-1-Ig, Clone: 1C11A9 ) at dilution of 1:800 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

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  IF Staining of Jurkat using 66801-1-Ig (same clone as 66801-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed Jurkat cells using CCR6 antibody (66801-1-Ig, Clone: 1C11A9 ) at dilution of 1:800 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

66801-1-PBS bindet in IHC, IF/ICC, IF-P, ELISA CCR6 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: CCR6 fusion protein Ag24195
• Vollständiger Name: chemokine (C-C motif) receptor 6
• Berechnetes Molekulargewicht: 42 kDa
• GenBank-Zugangsnummer: BC037960
• Gene symbol: CCR6
• Gene ID (NCBI): 1235
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CCR6, also known as CD196, is a C-C chemokine receptor that belongs to family A of G protein-coupled receptor superfamily. It is expressed in most B cells, memory T cells, and some subsets of dendritic cells (PMID: 17057190). CCR6 is a receptor for the C-C type chemokine CCL20 (PMID: 9169459). The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells, effector/memory T-cells, and B-cells and plays a role in skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis (PMID: 12948524). CCR6 polymorphism has been associated with rheumatoid arthritis susceptibility and CCR6 is involved in IL-17-driven autoimmunity in human diseases (PMID: 20453841).