CD117/c-Kit Rekombinanter Antikörper

CD117/c-Kit Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

CoraLite®594 Fluorescent Dye

CloneNo.

240246C11

Kat-Nr. : CL594-98041

Synonyme

CD117, Kit, 240246C11, c KIT

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  FC experiment of mouse bone marrow cells using CL594-98041

  1x10^6 mouse bone marrow cells were surface stained with CoraLite® Plus 488 Anti-Mouse CD45R, and 0.25 ug CoraLite®594 Anti-Mouse CD117/c-Kit Rabbit Recombinant Antibody (CL594-98041, Clone: 240246C11) or Isotype Control. Cells were not fixed.

• 

  FC experiment of mouse bone marrow cells using CL594-98041

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug CoraLite®594 Anti-Mouse CD117/c-Kit Rabbit Recombinant Antibody (CL594-98041, Clone: 240246C11) (red) or Isotype Control (blue). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Maus-Knochenmarkzellen

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

CL594-98041 bindet in FC CD117/c-Kit und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD117/c-Kit fusion protein Eg0883
• Vollständiger Name: kit oncogene
• Berechnetes Molekulargewicht: 109 kDa
• GenBank-Zugangsnummer: NM_001122733.1
• Gene symbol: CD117
• Gene ID (NCBI): 16590
• Konjugation: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

CD117, also known as c-Kit and SCFR, is a transmembrane protein with tyrosine kinase activity encoded by the oncogene c-kit (PMID: 2448137). It is a member of the type III receptor tyrosine kinase family, which also includes CSF-1R, PDGFRβ, PDGFRα, and FLT3 (PMID: 29518044). CD117 is expressed on hematopoietic stem cells and progenitor cells, mast cells, and is also found in a wide range of non-haemopoietic cell types (including melanocytes, germ cells, astrocytes, renal tubules, breast glandular epithelial cells, sweat glands, and interstitial cells of Cajal) (PMID: 10582338; 23073628). CD117 plays an important role in early haemopoiesis. It is also involved in pigmentation, fertility, gut movement, and some aspects of the nervous system (PMID: 23073628).