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CD11b Monoklonaler Antikörper

CD11b Monoklonal Antikörper für FC

Wirt / Isotyp

Ratte / IgG2b, kappa

Getestete Reaktivität

human, Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

M1/70

Kat-Nr. : 65055-1-PBS

Synonyme

M1/70, Ly 40, Itgam, integrin alpha M, CR3A

Filter:
  • Flow cytometry (FC) experiment of mouse bone marrow cells using Anti-Mouse CD11b (M1/70) (65055-1-Ig)

    FC experiment of mouse bone marrow cells using 65055-1-Ig (same clone as 65055-1-PBS)

    1X10^6 mouse bone marrow cells were surface stained with 0.2 ug Anti-Mouse CD11b (65055-1-Ig, Clone: M1/70) or 0.2 ug Isotype Control. Cells were not fixed. This data was developed using the same antibody clone with 65055-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

65055-1-PBS bindet in FC CD11b und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Ratte / IgG2b, kappa
Klonalität Monoklonal
Typ Antikörper
Immunogen C57BL/10 Mausmilz-T-Zellen und Concanavalin A-aktivierte C57BL/10-Splenozyten
Vollständiger Name integrin alpha M
Berechnetes Molekulargewicht127 kDa
GenBank-ZugangsnummerBC156991
Gene symbol CD11b
Gene ID (NCBI) 16409
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).