CD11b Rekombinanter Antikörper

CD11b Rekombinant Antikörper für FC

Wirt / Isotyp

Ratte / IgG2a

Getestete Reaktivität

human, Maus

Anwendung

FC

Konjugation

APC Fluorescent Dye

CloneNo.

M1/70

Kat-Nr. : APC-65672

Synonyme

CR3, CR3A, integrin alpha M, Itgam, Ly 40

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  FC experiment of mouse bone marrow cells using APC-65672

  1x10^6 mouse bone marrow cells were surface stained with PE Anti-Mouse Ly-6G, and 0.1 ug APC Anti-Mouse CD11b (M1/70) Rat IgG2a RecAb (APC-65672, Clone: M1/70) or APC Rat IgG2a Isotype Control (2A3) (APC-65209, Clone: 2A3). Cells were not fixed.

• 

  FC experiment of mouse bone marrow cells using APC-65672

  1x10^6 mouse bone marrow cells were surface stained with 0.1 ug APC Anti-Mouse CD11b (M1/70) Rat IgG2a RecAb (APC-65672, Clone: M1/70) (red) or APC Rat IgG2a Isotype Control (2A3) (APC-65209, Clone: 2A3) (blue). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Maus-Knochenmarkzellen

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

APC-65672 bindet in FC CD11b und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Ratte / IgG2a
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: k.A.
• Vollständiger Name: integrin alpha M
• Berechnetes Molekulargewicht: 127 kDa
• GenBank-Zugangsnummer: BC156991
• Gene symbol: CD11b
• Gene ID (NCBI): 16409
• Konjugation: APC Fluorescent Dye
• Excitation/Emission maxima wavelengths: 650 nm / 660 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).