CD11c Monoklonaler Antikörper

CD11c Monoklonal Antikörper für FC

Wirt / Isotyp

Maus / Mouse IgG1, kappa

Getestete Reaktivität

human

Anwendung

FC

Konjugation

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

BU15

Kat-Nr. : CL488-65196

Synonyme

CD11C, Integrin alpha X, ITGAX, Leu M5, SLEB6



Geprüfte Anwendungen

Erfolgreiche Detektion in FChumane Granulozyten aus peripherem Blut

Empfohlene Verdünnung

AnwendungVerdünnung
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 μl per 10^6 cells in a 100 µl suspension or 5 μl per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Produktinformation

CL488-65196 bindet in FC CD11c und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / Mouse IgG1, kappa
Klonalität Monoklonal
Typ Antikörper
Immunogen Humane dendritische Zellen aus Synovialflüssigkeit
Vollständiger Name integrin, alpha X (complement component 3 receptor 4 subunit)
Berechnetes Molekulargewicht 1169 aa, 129 kDa
GenBank-ZugangsnummerBC038237
Gene symbol ITGAX
Gene ID (NCBI) 3687
Konjugation CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission maxima wavelengths493 nm / 522 nm
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS mit 0,1% Natriumazid und 0,5% BSA, pH 7,3.
LagerungsbedingungenBei 2-8°C lagern. Vor Licht schützen.

Hintergrundinformationen

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression on most dendritic cells, CD11c is typically considered to be a marker of conventional dendritic cells (PMID: 27119555). CD11c forms an α/β heterodimer with CD18 (integrin β2). CD11c/CD18 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533).

Protokolle

Produktspezifische Protokolle
FC protocol for CL Plus 488 CD11c antibody CL488-65196Protokoll herunterladen
Standard-Protokolle
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