CD155/PVR Rekombinanter Antikörper

CD155/PVR Rekombinant Antikörper für FC

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

SKII.4

Kat-Nr. : 65632-1-PBS

Synonyme

PVR, CD155, HVED, Necl 5, NECL5

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  FC experiment of human PBMCs using 65632-1-MR (same clone as 65632-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD155/PVR (SKII.4) Mouse IgG2a Recombinant Antibody (65632-1-MR, Clone: SKII.4) or Mouse IgG2a Isotype Control, and PE-conjugated Goat Anti-Mouse IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. Monocytes were gated. This data was developed using the same antibody clone with 65632-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 65632-1-MR (same clone as 65632-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD155/PVR (SKII.4) Mouse IgG2a Recombinant Antibody (65632-1-MR, Clone: SKII.4) (red) or Mouse IgG2a Isotype Control (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. Monocytes were gated. This data was developed using the same antibody clone with 65632-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

65632-1-PBS bindet in FC CD155/PVR und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: SK-N-AS human neuroblastoma cells
• Vollständiger Name: poliovirus receptor
• Berechnetes Molekulargewicht: 45 kDa
• GenBank-Zugangsnummer: BC015542
• Gene symbol: CD155/PVR
• Gene ID (NCBI): 5817
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD155, also known as PVR, is a type I transmembrane glycoprotein in the immunoglobulin superfamily. It contains three extracellular immunoglobulin-like domains, D1-D3, of which D1 is recognized by the virus. Mature human CD155 consists of a 323 amino acid extracellular domain with one N-terminal V-type and two C2-type Ig-like domains, a 24 amino acid transmembrane segment, and a 50 amino acid cytoplasmic tail. CD155 is thought to play a role in adhesion by interaction with the ECM component vitronectin as well as a role in NK killing of tumor cells. CD155 binds to two receptors of NK cells, CD96 and CD226, and accumulates at cell-cell contact sites, leading to the formation of mature immune synapses between NK cells and target cells. CD155 serves as the entry receptor for poliovirus and thereby mediates human susceptibility to poliovirus infection.