CD155/PVR Rekombinanter Antikörper

CD155/PVR Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

240731B1

Kat-Nr. : 98077-1-RR

Synonyme

Pvr, Tage4, poliovirus receptor, CD155, 240731B1

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  FC experiment of mouse thymocytes using 98077-1-RR

  1x10^6 mouse thymocytes were surface stained with 0.25 ug Anti-Mouse CD155/PVR Rabbit Recombinant Antibody (98077-1-RR, Clone:240731B1) or isotype control and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG. Cells were not fixed.

• 

  FC experiment of mouse thymocytes using 98077-1-RR

  1x10^6 mouse thymocytes were surface stained with 0.25 ug Anti-Mouse CD155/PVR Rabbit Recombinant Antibody (98077-1-RR, Clone:240731B1) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98077-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98077-1-RR against Mouse CD155/PVR were performed. The affinity constant is 0.649 nM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Maus-Thymozyten

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98077-1-RR bindet in FC CD155/PVR und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: poliovirus receptor
• Berechnetes Molekulargewicht: 45 kDa
• GenBank-Zugangsnummer: NM_027514.2
• Gene symbol: CD155/PVR
• Gene ID (NCBI): 52118
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

CD155, also known as the poliovirus receptor (PVR) or Necl-5, is one of the nectin-like family members, belonging to the Ca2+ independent immunoglobulin superfamily (IgSF) in cell adhesion molecules (PMID: 37660884). CD155 is a type I transmembrane protein composed of three extracellular immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail. It is involved in cell-to-cell and cell-to-ECM adhesion (PMID: 32019260; 11437656). CD155 acts as a ligand for immune receptors, including TIGIT, CD96 and CD226, which are expressed on T cells and NK cells. CD155 interacts with these receptors to modulate immune responses, such as T cell activation and NK cell-mediated cytotoxicity (PMID: 37660884). CD155 serves as the entry receptor for poliovirus and thereby mediates susceptibility to poliovirus infection (PMID: 15034010).