CD155/PVR Rekombinanter Antikörper

CD155/PVR Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241405G8

Kat-Nr. : 98186-1-PBS

Synonyme

PVR, NECL-5, NECL5, Necl 5, HVED

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  FC experiment of human PBMCs using 98186-1-RR (same clone as 98186-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD155/PVR Rabbit Recombinant Antibody (98186-1-RR, Clone: 241405G8) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98186-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98186-1-RR (same clone as 98186-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD155/PVR Rabbit Recombinant Antibody (98186-1-RR, Clone: 241405G8) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98186-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98186-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98186-1-RR against Human CD155/PVR were performed. The affinity constant is 95.9 nM.

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Geprüfte Anwendungen

Produktinformation

98186-1-PBS bindet in FC CD155/PVR und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: poliovirus receptor
• Berechnetes Molekulargewicht: 45 kDa
• GenBank-Zugangsnummer: BC015542
• Gene symbol: CD155/PVR
• Gene ID (NCBI): 5817
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD155, also known as PVR, is a type I transmembrane glycoprotein in the immunoglobulin superfamily. It contains three extracellular immunoglobulin-like domains, D1-D3, of which D1 is recognized by the virus. Mature human CD155 consists of a 323 amino acid extracellular domain with one N-terminal V-type and two C2-type Ig-like domains, a 24 amino acid transmembrane segment, and a 50 amino acid cytoplasmic tail. CD155 is thought to play a role in adhesion by interaction with the ECM component vitronectin as well as a role in NK killing of tumor cells. CD155 binds to two receptors of NK cells, CD96 and CD226, and accumulates at cell-cell contact sites, leading to the formation of mature immune synapses between NK cells and target cells. CD155 serves as the entry receptor for poliovirus and thereby mediates human susceptibility to poliovirus infection.