CD19 Rekombinanter Antikörper

CD19 Rekombinant Antikörper für FC

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

Kaninchen

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242570A11

Kat-Nr. : 98351-1-PBS

Synonyme

CD19 molecule

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  FC experiment of rabbit splenocytes using 98351-1-MR (same clone as 98351-1-PBS)

  1x10^6 rabbit splenocytes were surface stained with 0.25 ug Anti-Rabbit CD19 Mouse RecAb (98351-1-MR, Clone:242570A11) .or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4)and PE-conjugated Goat Anti-Mouse IgG. Cells were then stained with Anti-Rabbit FITC-CD4. Cells were not fixed. This data was developed using the same antibody clone with 98351-1-PBS in a different storage buffer formulation.

• 

  FC experiment of rabbit splenocytes using 98351-1-MR (same clone as 98351-1-PBS)

  1x10^6 rabbit splenocytes were surface stained with 0.25 ug Anti-Rabbit CD19 Mouse RecAb (98351-1-MR, Clone:242570A11)(red).or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4)and PE-conjugated Goat Anti-Mouse IgG(blue). Cells were not fixed. This data was developed using the same antibody clone with 98351-1-PBS in a different storage buffer formulation.

• 

  FC experiment of rabbit splenocytes using 98351-1-MR (same clone as 98351-1-PBS)

  1x10^6 rabbit splenocytes were surface stained with 0.25 ug Anti-Rabbit CD19 Mouse RecAb (98351-1-MR, Clone:242570A11).or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4)and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed. This data was developed using the same antibody clone with 98351-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98351-1-PBS bindet in FC CD19 und zeigt Reaktivität mit Kaninchen

• Getestete Reaktivität: Kaninchen
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD19 fusion protein Eg3526
• Vollständiger Name: CD19
• Gene symbol: CD19
• Gene ID (NCBI): 100345233
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD19 is a 95 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily (PMID: 2472450). It is expressed by B cells and follicular dendritic cells. CD19 is up-regulated at the step of B-lineage commitment during the differentiation of the hematopoietic stem cell, it remains on during subsequent stages of differentiation until finally down-regulated during terminal differentiation into plasma cells (PMID: 8528044). CD19 is involved in B cell development, activation and differentiation. It is the dominant component for the signaling complex on B cells that includes CD21 (CR2), CD81 (TAPA-1) and CD225 and acts as a critical co-receptor for BCR signal transduction (PMID: 23210908).