CD200 Rekombinanter Antikörper

CD200 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241329G4

Kat-Nr. : 98091-2-PBS

Synonyme

241329G4, CD200 molecule, MOX1, MOX2, MRC

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  FC experiment of human PBMCs using 98091-2-RR (same clone as 98091-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD200 Rabbit RecAb (98091-2-RR, Clone: 241329G4) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD19. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98091-2-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98091-2-RR (same clone as 98091-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD200 Rabbit RecAb (98091-2-RR, Clone: 241329G4) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98091-2-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98091-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98091-2-RR against Human CD200 were performed. The affinity constant is 0.405 nM.

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Geprüfte Anwendungen

Produktinformation

98091-2-PBS bindet in FC CD200 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: CD200 molecule
• Berechnetes Molekulargewicht: 269 aa, 30 kDa
• GenBank-Zugangsnummer: BC022522
• Gene symbol: CD200
• Gene ID (NCBI): 4345
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD200, also known as OX2, is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily (PMID: 3032785). It contains two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. CD200 is expressed on a variety of cell types, including thymocytes, B lymphocytes, a subset of T lymphocytes, follicular dendritic cells, neurons, and endothelial cells (PMID: 3032785; 10981966). CD200 binds to its receptor, CD200R, which is primarily expressed by myeloid and T cell lineage (PMID: 15187158). The CD200-CD200R interaction plays a role in immunosuppression and suppression of anti-tumor immune responses (PMID: 22020332).