CD206 Monoklonaler Antikörper
CD206 Monoklonal Antikörper für FC
Wirt / Isotyp
Maus / IgG1, kappa
Getestete Reaktivität
human
Anwendung
FC
Konjugation
FITC Plus Fluorescent Dye
CloneNo.
15-2
Kat-Nr. : FITC-65155
Synonyme
Geprüfte Anwendungen
| Erfolgreiche Detektion in FC | GM-CSF treated human PBMCs | 
Empfohlene Verdünnung
| Anwendung | Verdünnung | 
|---|---|
| This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. | |
| Sample-dependent, check data in validation data gallery | |
Veröffentlichte Anwendungen
| FC | See 12 publications below | 
Produktinformation
FITC-65155 bindet in FC CD206 und zeigt Reaktivität mit human
| Getestete Reaktivität | human | 
| In Publikationen genannte Reaktivität | human | 
| Wirt / Isotyp | Maus / IgG1, kappa | 
| Klonalität | Monoklonal | 
| Typ | Antikörper | 
| Immunogen | Gereinigter humaner Mannose-Rezeptor | 
| Vollständiger Name | mannose receptor, C type 1 | 
| Berechnetes Molekulargewicht | 166 kDa | 
| GenBank-Zugangsnummer | NM_002438 | 
| Gene symbol | CD206 | 
| Gene ID (NCBI) | 4360 | 
| Konjugation | FITC Plus Fluorescent Dye | 
| Excitation/Emission maxima wavelengths | 495 nm / 524 nm | 
| Form | Liquid | 
| Reinigungsmethode | Der gereinigte Antikörper ist mit Fluoresceinisothiocyanat (FITC) unter optimalen Bedingungen konjugiert. Das Konjugat wird mit Größenausschluss-Chromatographie gereinigt. | 
| Lagerungspuffer | PBS with 0.09% sodium azide and 0.5% BSA | 
| Lagerungsbedingungen | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. | 
Hintergrundinformationen
CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.
Protokolle
| PRODUKTSPEZIFISCHE PROTOKOLLE | |
|---|---|
| FC protocol for FITC Plus CD206 antibody FITC-65155 | Download protocol | 
| STANDARD-PROTOKOLLE | |
|---|---|
| Klicken Sie hier, um unsere Standardprotokolle anzuzeigen | 
Publikationen
| Species | Application | Title | 
|---|---|---|
| Biochim Biophys Acta Mol Basis Dis Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages | ||
| Front Immunol Chamaejasmenin B, an Inhibitor for Metastatic Outgrowth, Reversed M2-Dominant Macrophage Polarization in Breast Tumor Microenvironment. | ||
| Pharm Biol Schizandrin A ameliorates cognitive functions via modulating microglial polarisation in Alzheimer's disease mice. | ||
| Cancer Sci Homeobox A7 promotes esophageal squamous cell carcinoma progression through C-C motif chemokine ligand 2-mediated tumor-associated macrophage recruitment | ||
| J Biochem Mol Toxicol KLF4-induced upregulation of SOCS1 ameliorates myocardial ischemia/reperfusion injury by attenuating AC16 cardiomyocyte damage and enhancing M2 macrophage polarization | ||
