CD268/BAFF-R Rekombinanter Antikörper

CD268/BAFF-R Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242003A1

Kat-Nr. : 98254-1-RR

Synonyme

TNFRSF13C, B-cell-activating factor receptor, BAFF-R, BAFFR, BAFF receptor

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  FC experiment of human PBMCs using 98254-1-RR

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD268/BAFF-R Rabbit Recombinant Antibody (98254-1-RR, Clone: 242003A1) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human CD19. Cells were not fixed.

• 

  FC experiment of human PBMCs using 98254-1-RR

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD268/BAFF-R Rabbit Recombinant Antibody (98254-1-RR, Clone: 242003A1)(red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: humane PBMCs

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98254-1-RR bindet in FC CD268/BAFF-R und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 13C
• Berechnetes Molekulargewicht: 184 aa, 19 kDa
• GenBank-Zugangsnummer: BC105123
• Gene symbol: TNFRSF13C
• Gene ID (NCBI): 115650
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

B-cell-activating factor receptor (BAFF-R, also known as CD268 and TNFRSF13C) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in most malignant B cells, including those in primary central nervous system lymphoma (PCNSL), and is involved in the survival and proliferation of these cells (PMID: 32528875). The interaction of BAFF with BAFF-R promotes NF-κB activation, which plays a crucial role in B-cell maturation, survival, and costimulation of T-cell activation and proliferation (PMID: 30349534). Additionally, BAFF-R is associated with chronic kidney disease (CKD) by activating NF-κB signaling in renal tubular epithelial cells (PMID: 38791453).