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CD268/BAFF-R Rekombinanter Antikörper

CD268/BAFF-R Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

243120H8

Kat-Nr. : 98404-1-PBS

Synonyme

BAFF receptor, Baffr, BAFF-R, B-cell maturation defect, B-cell-activating factor receptor

Filter:
  • Flow cytometry (FC) experiment of mouse splenocytes using Anti-Mouse CD268/BAFF-R Rabbit Recombinant Antibod (98404-1-RR)

    FC experiment of mouse splenocytes using 98404-1-RR (same clone as 98404-1-PBS)

    1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD268/BAFF-R Rabbit RecAb (98404-1-RR, Clone: 243120H8) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 488 Anti-Mouse CD19. Cells were not fixed. This data was developed using the same antibody clone with 98404-1-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of mouse splenocytes using Anti-Mouse CD268/BAFF-R Rabbit Recombinant Antibod (98404-1-RR)

    FC experiment of mouse splenocytes using 98404-1-RR (same clone as 98404-1-PBS)

    1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD268/BAFF-R Rabbit RecAb (98404-1-RR, Clone: 243120H8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98404-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

98404-1-PBS bindet in FC CD268/BAFF-R und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen CD268/BAFF-R fusion protein Eg1840
Vollständiger Name tumor necrosis factor receptor superfamily, member 13c
Berechnetes Molekulargewicht19 kDa
GenBank-ZugangsnummerNM_028075.2
Gene symbol Tnfrsf13c
Gene ID (NCBI) 72049
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

B-cell-activating factor receptor (BAFF-R, also known as CD268 and TNFRSF13C) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in most malignant B cells, including those in primary central nervous system lymphoma (PCNSL), and is involved in the survival and proliferation of these cells (PMID: 32528875). The interaction of BAFF with BAFF-R promotes NF-κB activation, which plays a crucial role in B-cell maturation, survival, and costimulation of T-cell activation and proliferation (PMID: 30349534). Additionally, BAFF-R is associated with chronic kidney disease (CKD) by activating NF-κB signaling in renal tubular epithelial cells (PMID: 38791453).